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Concomitant administration of the enzyme-inducing agent rifampicin with fluconazole result in reduced serum concentrations of fluconazole. Administration of hydrochlorothiazide and fluconazole has resulted in clinically insignificant increases in serum-fluconazole concentrations.
Fluconazole may interfere with the metabolism of some drugs if given concomitantly. This may account for the reported increases in plasma concentrations of phenytoin, sulfonylurea, hypoglycaemic agents, cyclosporin, nortriptyline and zidovudine. Increases in terfenadine concentrations following high doses of fluconazole have been associated with ECG abnormalities. Fluconazole may also increase the effect of some oral anticoagulants and reduce the clearance of theophylline.
